The opportunities with the Vivostat® Co-Delivery system are vast and the system allows the surgeon to apply a selected substance easily and effectively. Furthermore, it may be possible to reduce the total cost of a procedure by using
the Vivostat® Co-Delivery system.

Options for Co-Delivery include:

Drugs

• Antimicrobials
• Chemotherapeutics
• Pain medications

Cells

• Stem cells
• Skin cells

Co-delivering drugs, cells etc. with the Vivostat® Fibrin Sealant or Vivostat PRF® solutions offers the surgeon and the patient a number of benefits:

• Topical application
• Targeting affected/desired area
• Possible higher local dose
• Possible lower systemic impact
• Improved compliance

Moreover, no thrombin is added to Vivostat® Fibrin Sealant and Vivostat PRF® (unlike most other sealants and PRP products). This is beneficial to the Co-Delivery system as thrombin activation has been shown to have a negative
effect on cell survival.

The fibrin membrane found in both Vivostat® Fibrin Sealant and Vivostat PRF® has, furthermore, been shown to postpone the degradation process of the substance. This means that the fibrin membrane ensures a slow and sustained release of the substance offering a prolonged effect.

How does it work

Up to 5 ml of substance may be co-delivered together with the Fibrin or PRF® solution. The substance is applied using
the Vivostat® Spraypen which enables the surgeon to apply the substance accurately and intermittently throughout the entire procedure. The substance and the Fibrin or PRF® solution is mixed once it leaves the tip of the Spraypen and polymerizes immediately upon application – this way the substances stay where they are intended to act.